Sex difference in human mevalonate metabolism.
نویسندگان
چکیده
منابع مشابه
Sex difference in human mevalonate metabolism.
Two pathways of mevalonate metabolism have been demonstrated: the major (sterol) pathway leads to cholesterol synthesis, whereas the second shunts mevalonate away from sterol production and ultimately results in its oxidation to CO2. Previous studies have demonstrated that the female rat metabolizes circulating mevalonate by the shunt pathway at twice the rate of the male, whereas the male rat ...
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Previous studies from this laboratory have demonstrated that the kidneys represent the major tissue site for the metabolism of circulating mevalonic acid by both the sterol and nonsterol pathways of mevalonate utilization. These earlier conclusions were based solely on observations in male rats; therefore, the present studies were carried out in both male and female rats to evaluate possible se...
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Previous studies from this laboratory have demonstrated that the kidneys rather than the liver play the major role in the in vivo metabolism of circulating mevalonic acid. Kidneys, however, convert mevalonic acid primarily to the precursors of cholesterol, squalene and lanosterol, rather than to cholesterol. This study was designed to define the specific tissue site within the kidney responsibl...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1980
ISSN: 0021-9738
DOI: 10.1172/jci109864